产品特点
提高检出率,胃肠癌“早”发现,“早”干预
双基因甲基化血液检测
癌胚抗原、糖类抗原等5项血清肿瘤标志物检测
胃肠癌高风险人群,通常会有这些问题?
1、经常便秘腹泻交替,长期肠胃不适
2、食欲减退,体重莫名减轻,不明原因腹胀
3,有慢性肠胃病史,有肠胃道息肉史,有胃癌、结直肠癌家族史
胃癌+肠癌,其实离我们很近
胃肠道癌症“ 是潜在的“健康杀手
胃肠道癌症初期 多为无明显症状,
90%患者发现即为中晚期!
所以需要早期筛查,早发现,早干预,避免错失痊愈黄金时机。
检测意义
双基因甲基化检测同时针对胃癌+肠癌早筛,高性价比
同时检测血清与胃肠癌相关的肿瘤标志物,提高检出率
互联网医院支持,医生在线报告解读,给出详细体检及健康建议
足不出户,护士上门采样,同时进行胃癌与肠癌早筛检测,真方便!
检测内容---胃肠癌基因甲基化检测+肿瘤标志物检测
A*基因甲基化---对肠癌筛查的灵敏度较高,同时也能检出息肉、腺瘤等
B*基因甲基化---与患胃癌密切相关,也能检出慢性胃炎、胃内瘤变等
癌胚抗原(CEA)-----CEA和CA72-4链接检测敏感度93.59%,准确度88.6%
糖类抗原19-9(CA19-9)---CA19-9在胃癌中特异性为95.9%
糖类抗原72-4(CA72-4)---CA72-4在胃癌中特异性为93.83%
糖类抗原50(CA50)---CA50联合其他肿瘤标志物能提高对于早期胃癌、肠癌的灵敏度
糖类抗原242(CA242)---CA242联合其他肿瘤标志物在早期胃癌、肠癌中具有良好的意义
*A基因、B基因为代名词,具体甲基化基因请咨询客服了解详情
适用人群
家族有肿瘤病患者;
长期饮酒、吸烟者,饮食不健康导致的肥胖者;
还怕做肠胃镜;
慢性肠胃炎疾病;
持续性便血、腹部隐痛腹胀;
样本类型
静脉血
检测流程
参考文献:
[1] Hye, Seung, Lee, et al. Circulating Methylated Septin 9 Nucleic Acid in the Plasma of Patients with Gastrointestinal Cancer in the Stomach and Colon[J]. Translational Oncology, 2013.
[2]Cao C Q , Chang L , Wu Q . Circulating methylated Septin 9 and ring finger protein 180 for noninvasive diagnosis of early gastric cancer[J]. Translational Cancer Research, 2020, 9(11):7012-7021.
[3] Kin‐Fai Cheung, Lam C N Y , Wu K , et al. Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer[J]. Cancer, 2012, 118.
[4]Deng J , Liang H , Ying G , et al. Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer[J]. Oncotarget, 2014, 5(10):3173- 83.
[5] Han F , Sun L P , Liu S , et al. Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis.[J]. Oncotarget, 2016, 7(17):24800-24809.
[6]Han F , Liu S , Jing J , et al. Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer[J]. Cancer Management and Research, 2020, Volume 12:3389-3399.
[7]Advances in serum biomarkers for early diagnosis of gastric cancer DIO:10.3785/j.issn.1008-9292.2019.06.14
[8]血清胃蛋白酶原与肿瘤标志物CEA、CA199、CA242、CA724联合检测对胃癌诊断的价值分析
[9]谢海涛;;肿瘤标志物CA724、CA199、CA242、CEA联合检测在老年胃癌诊断中的应用[J];中国老年学杂志;2017年01期
[10]血清肿瘤标志物CA50、CA199水平检测在结直肠癌临床诊断中的应用 10.3969/j.issn.1007-614x.2016.33.79